Identification of Penexanthone A as a Novel Chemosensitizer to Induce Ferroptosis by Targeting Nrf2 in Human Colorectal Cancer Cells
Ferroptosis has emerged as a potential mechanism for enhancing the efficacy of chemotherapy in cancer treatment.By suppressing nuclear factor erythroid 2-related factor 2 (Nrf2), cancer cells may lose their ability to Bag Cutters counteract the oxidative stress induced by chemotherapy, thereby becoming more susceptible to ferroptosis.In this study,